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磷酸化水通道蛋白2抗體
  • 產(chǎn)品貨號：
    BN41014R
  • 中文名稱：
    磷酸化水通道蛋白2抗體
  • 英文名稱：
    Rabbit anti-phospho-AQP2 (Ser264+261) Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41014R-100ul

    100ul

    ￥2470.00

    交叉反應：Dog(predicted:Human,Mouse,Rat,Chicken,Pig,Cow,Sheep) 推薦應用：WB,ELISA

產(chǎn)品描述

英文名稱phospho-AQP2 (Ser264+261)
中文名稱磷酸化水通道蛋白2抗體
別    名Aquaporin 2 (phospho S261); p-Aquaporin 2 (phospho S261) ADH water channel; AQP 2; AQP CD; AQP2; AQPCD; Aquaporin 2 collecting duct; Aquaporin CD; Aquaporin2; Aquaporine 2; Collecting duct water channel protein; MGC34501; Water channel protein for renal collecting duct; WCH CD; WCHCD.  
產(chǎn)品類型磷酸化抗體 
研究領域腫瘤  細胞生物  信號轉導  通道蛋白  細胞粘附分子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Dog,  (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Sheep, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量30kDa
細胞定位細胞漿 細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthesised phosphopeptide derived from human AQP2 around the phosphorylation site of Ser264/261:LH(p-S)PQ(p-S)LP <Cytoplasmic>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant, and recessive forms of nephrogenic diabetes insipidus. Belongs to the MIP/aquaporin (TC 1.A.8) family.

Function:
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.

Subcellular Location:
Apical cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Shuttles from vesicles to the apical membrane.

Tissue Specificity:
Expressed in renal collecting tubules.

Post-translational modifications:
Ser-256 phosphorylation is necessary and sufficient for expression at the apical membrane. Endocytosis is not phosphorylation-dependent.

DISEASE:
Defects in AQP2 are the cause of diabetes insipidus nephrogenic autosomal (ANDI) [MIM:125800]; also known as diabetes insipidus nephrogenic type 2. ANDI is caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. It is characterized by excessive water drinking (polydypsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia. Inheritance can be autosomal dominant or recessive.

Similarity:
Belongs to the MIP/aquaporin (TC 1.A.8) family.

SWISS:
P41181

Gene ID:
359

Database links:

Entrez Gene: 359 Human

Entrez Gene: 11827 Mouse

Entrez Gene: 25386 Rat

Omim: 107777 Human

SwissProt: P41181 Human

SwissProt: P56402 Mouse

SwissProt: P34080 Rat

Unigene: 130730 Human

Unigene: 20206 Mouse

Unigene: 90076 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


















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